Thrombocytopaenia: a serious side effect of diazoxide

Author:

Thus Kirsten A,den Boogert Wilhelmina J,van der Heyden Josefine C

Abstract

A 2.5-year-old boy with a history of (transient) congenital hyperinsulinism was admitted to the paediatric ward with recurrent hypoglycaemia. Diazoxide 5 mg/kg/day and hydrochlorothiazide 2 mg/kg/day were initiated. After increasing the dose of diazoxide to 10 mg/kg/day, the child developed mild rectal bleeding, petechiae, epistaxis and haematemesis. Blood screening showed severe thrombocytopaenia. Diazoxide and hydrochlorothiazide were stopped, and his platelet count normalised. Drug rechallenge was positive. Drug-induced immune thrombocytopaenia was diagnosed.

Publisher

BMJ

Subject

General Medicine

Reference6 articles.

1. Hematologic reactions to diazoxide;Combs;Pediatrics,1967

2. Thrombocytopenia induced by diazoxide in a patient with an insulinoma;Adachi;Intern Med,2014

3. Hematological side-effects of diazoxide;Wales;Lancet,1967

4. Prevalence of adverse events in children with congenital hyperinsulinism treated with diazoxide;Herrera;J Clin Endocrinol Metab,2018

5. Hyperinsulinaemic hypoglycaemia:genetic mechanisms, diagnosis and management;Mohamed;J Clin Res Pediatr Endocrinol,2012

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