Methotrexate and doxycycline interaction: a rare cause of pancytopenia

Author:

Arslan Ahmad,Zain Muhammad Abdullah,Mukhtar Maryam,Ullah WaqasORCID,Roomi Sohaib

Abstract

Methotrexate (MTX) was originally formulated as one of the first antitumour drugs due to its ability to alter folate metabolism, which renders it to be an antiproliferative agent. Classically, the higher dosage is administered via parenteral route, in a cyclical fashion, to achieve antitumour effects. Patients on high doses of MTX are prone to develop rare complications of myelosuppression and pancytopenia, in a dose-dependent fashion, secondary to altered folate metabolism. 1 Herein, we present a unique case of rheumatoid arthritis presented with pancytopenia due to low-dose MTX and doxycycline drug interaction. We also report the successful management of pancytopenia and oral ulcers with combination therapy of leucovorin and granulocyte colony-stimulating factor.

Publisher

BMJ

Subject

General Medicine

Cited by 3 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. A critical review of methotrexate clinical interactions: role of transporters;Expert Opinion on Drug Metabolism & Toxicology;2023-02-01

2. Medikamente auf Reisen mit entzündlich-rheumatischer Grunderkrankung;Zeitschrift für Rheumatologie;2021-08-13

3. Doxycycline/methotrexate interaction;Reactions Weekly;2019-07

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