1. Prevention of pseudomonas colonisation. In view of the inevitable occurrence of bacterial colonisation and infection of the respiratory tract, aerosol antibiotic prophylaxis from the time of diagnosis has been recommended by some clinics (San Diego Experience, Perspectives in Cystic Fibrosis, 1980). The use of regular aerosol aminoglycosides from infancy has been associated with a reduction in respiratory symptoms (M Zach 1992, personal communication). This is probably a particularly important area as evidence is accumulating indicating that it is easier to prevent P aeruginosa colonising the respiratory tract than to eradicate the organism once established. 17 Ceftazidime, a third generation cephalosporin, has also been used.' 12 The third generation cephalosporins have good antipseudomonal and Haemophilus influenzae activity but poor staphylococcal activity
2. Aerosol carbenicillin and gentamicin treatment of Pseudomonas aeruginosa infection in patients with cystic fibrosis;Hodson, M.E.; Penketh, A.R.L.; Batten, J.C.;Lancet,1981
3. Nebulised colomycin for early pseudomonas colonisation in cystic fibrosis;Littlewood, J.M.; Miller, M.G.; Ghonheim, A.T.; Ramsden, C.H.;Lancet,1985
4. Antibiotic prophylaxis in cystic fibrosis: inhaled cephaloridine as an adjunct to oral cloxacillin;Nolan, G.; McIvor, P.; Levison, H.; Fleming, P.C.; Corey, M.; Gold, R.,1982
5. Colistin inhalation thereapy in cystic fibrosis patients with chronic pseudomonas aeruginosa lung infection;Jensen, T.; Pedersen, S.S.; Game, S.; Heilmann, C.; Hoiby, N.; Koch, C.;IAAntimicrob Chemother,1987