Systemic infection following intravesical therapy with BCG

Author:

Oliveira Ana AndradeORCID,Morais JoanaORCID,Ribeiro Jorge,Gouveia Paulo Ferreira

Abstract

Immunotherapy with BCG is an effective and widely used treatment for non-muscle-invasive bladder cancer. BCG sepsis is a rare but life-threatening and frequently not a straightforward complication of this treatment; in cases with a high index of suspicion, anti-bacillary treatment should not wait for laboratory confirmation and be instituted immediately. We report a severe case of BCG sepsis, in which timely diagnosis and initiation of antituberculosis agents enabled a full recovery.

Publisher

BMJ

Subject

General Medicine

Reference21 articles.

1. Favorable outcome in a patient with systemic BCGitis after intra-bladder instillation of Calmette-Guerin Bacillus highlighting the importance of making the correct diagnosis in this rare form of sepsis;Attou;J Transl Int Med,2019

2. Bcg infection after bladder cancer Treatment—3 clinical case reports;Alves;Adv Infect Dis,2015

3. A case of ureteral obstruction and sepsis induced by bladder perforation following intravesical Bacillus Calmette-Guérin successfully treated with an antituberculous agent, antimicrobial chemotherapy and percutaneous urine drainage;Morooka;Int Cancer Conf J,2018

4. Disseminated Bacillus Calmette-Guérin (BCG) infection with pulmonary and renal involvement: a rare complication of BCG immunotherapy. A case report and narrative review;Marques;Pulmonology,2020

5. Intracavitary Bacillus Calmette-guerin in the Treatment of Superficial Bladder Tumors

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