Abstract
Frequently the cause of raised intracranial pressure remains unresolved and rarely is related to spinal tumours, moreover less to spinal medulloblastoma without primary brain focus. An 18-year-old woman had a 3-month history of headache and impaired vision. Neurological examination revealed bilateral sixth cranial nerve palsies with bilateral papilloedema of grade III. No focal brain or spine lesion was found on imaging. Consecutive lumbar punctures showed high opening pressure and subsequent increasing protein level. Meningeal biopsy was negative. At one point, she developed an increasing headache, vomiting and back pain. Spine MRI showed diffuse nodular leptomeningeal enhancement with the largest nodule at T6–T7. Malignant cells were detected in cerebrospinal fluid. She underwent laminectomy with excisional biopsy, and pathology showed medulloblastoma WHO grade IV. She was treated with chemotherapy and craniospinal irradiation and made a good recovery.
Reference22 articles.
1. Adams RA , Ropper AH . Principles of Neurology. 6th edn. New York: McGraw Hill, 1997.
2. Fishman R . Cerebrospinal fluid in diseases of the nervous system. Philadelphia: WB Saunders, 1980.
3. The Monro-Kellie hypothesis: Applications in CSF volume depletion
4. Cerebrospinal fluid circulation: What do we know and how do we know it?
5. Why would a spinal tumor cause increased intracranial pressure?;Rekate;J Neuroophthalmol,2002
Cited by
3 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献