Growth hormone treatment of growth failure secondary to total body irradiation and bone marrow transplantation.

Author:

Papadimitriou A,Urena M,Hamill G,Stanhope R,Leiper A D

Publisher

BMJ

Subject

Pediatrics, Perinatology and Child Health

Reference22 articles.

1. Patients with myeloid leukaemia were treated with daunorubicin, cytosine arabinoside, and thioguananine, or with two courses of this before one course of meta-amsacrine, azacytidine, and etoposide VP16 together with intrathecal cytosine arabinoside. Eight of those with lymphoblastic leukaemia had previously undergone cranial irradiation for the prevention of meningeal leukaemic infiltration in a dose of 1800 cGy (n=3) in 10 fractions over 12 days or 2400 cGy (n=5) in 15 fractions over 19 days. All the children with lymphoblastic disease also received intrathecal methotrexate. Eight patients had Papadimitriou, Uruena, Hamill, Stanhope, Leiper relapsed and were therefore given additional induction and consolidation chemotherapy before bone marrow transplantation. One boy (case 7) was also given treatment for testicular relapse with 2400 cGy testicular irradiation

2. Bone marrow transplantation: a review of delayed complications;Deeg, H.J.;Br J Haematol,1984

3. The effect of total body irradiation and bone marrow transplantation during childhood and adolescence on growth and endocrine function;Leiper, A.D.; Stanhope, R.; Lau, T.;Br J Haematol,1987

4. Growth and development following marrow transplantation for leukemia;Sanders, J.E.; Pritchard, S.; Mahoney, P.;Blood,1986

5. The effects of growth hormone therapy in children with radiation-induced growth hormone deficiency;Shalet, S.M.; Whitehead, C.; Chapman, A.J.; Beardwell, C.G.;Acta Paediatr Scand,1981

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