Author:
Tomee J F,Koëter G H,Hiemstra P S,Kauffman H F
Abstract
Secretory leukoprotease inhibitor (SLPI) is a low molecular weight serine protease inhibitor found on various mucosal surfaces and has been ascribed an important role in maintaining the protease-anti-protease balance of the airways. Recent scientific evidence has suggested that SLPI may also have a broad spectrum antibiotic activity that includes antiretroviral, bactericidal, and antifungal activity. Given the unpropitious development of drug resistance to infectious micro-organisms in the human population, the need for therapeutic alternatives in the treatment of infectious diseases has become clear. SLPI may prove valuable in the prophylaxis and future treatment of infectious diseases, yet the clinical efficacy of SLPI remains largely to be elucidated.
Subject
Pulmonary and Respiratory Medicine
Reference13 articles.
1. Secretory leukoprotease inhibitor: partnering 1-proteinase inhibitor to combat pulmonary inflammation;Bingle, L.; Tetley, T.D.;Thorax,1996
2. Antileukoprotease in sputum during bronchial infections;Dijkman, J.H.; Kramps, J.A.; Franken, C.;Chest,1986
3. Secretory leukocyte protease inhibitor: a macrophage product induced by and antagonistic to bacterial lipopolysaccharide;Jin, F.; Nathan, C.; Radzioch, D.; Ding, A.;Cell,1997
4. Inhibition of lipopolysaccharide-induced pulmonary emphysema by intratracheally instilled recombinant secretory leukocyte proteinase inhibitor;Rudolphus, A.; Stolk, J.; Dijkman, J.H.; Kramps, J.A.;Am Rev Respir Dis,1993
5. Secretory leukocyte protease inhibitor: a human saliva protein exhibiting anti-human immunodeficiency virus 1 activity in vitro;McNeely, T.B.; Dealy, M.; Dripps, D.J.; Orenstein, J.M.; Eisenberg, S.P.; Wahl, S.M.;J Clin Invest,1995
Cited by
86 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献