Baseline BMI and BMI variation during first line pembrolizumab in NSCLC patients with a PD-L1 expression ≥ 50%: a multicenter study with external validation
-
Published:2020-10
Issue:2
Volume:8
Page:e001403
-
ISSN:2051-1426
-
Container-title:Journal for ImmunoTherapy of Cancer
-
language:en
-
Short-container-title:J Immunother Cancer
Author:
Cortellini AlessioORCID, Ricciuti Biagio, Tiseo Marcello, Bria Emilio, Banna Giuseppe L, Aerts Joachim GJV, Barbieri Fausto, Giusti Raffaele, Cortinovis Diego L, Migliorino Maria R, Catino Annamaria, Passiglia Francesco, Torniai Mariangela, Morabito AlessandroORCID, Genova Carlo, Mazzoni Francesca, Di Noia Vincenzo, Signorelli Diego, Gelibter Alain, Occhipinti Mario Alberto, Rastelli Francesca, Chiari Rita, Rocco Danilo, Inno Alessandro, De Tursi Michele, Di Marino Pietro, Mansueto Giovanni, Zoratto Federica, Grossi Francesco, Filetti Marco, Pizzutilo Pamela, Russano Marco, Citarella Fabrizio, Cantini Luca, Targato Giada, Nigro Olga, Ferrara Miriam G, Buti Sebastiano, Scodes Simona, Landi Lorenza, Guaitoli Giorgia, Della Gravara Luigi, Tabbò Fabrizio, Ricciardi Serena, De Toma Alessandro, Friedlaender Alex, Petrelli Fausto, Addeo Alfredo, Porzio Giampiero, Ficorella Corrado
Abstract
BackgroundThe association between obesity and outcomes in patients receiving programmed death-1/programmed death ligand-1 (PD-L1) checkpoint inhibitors has already been confirmed in pre-treated non-small cell lung cancer (NSCLC) patients, regardless of PD-L1 tumor expression.MethodsWe present the outcomes analysis according to baseline body mass index (BMI) and BMI variation in a large cohort of metastatic NSCLC patients with a PD-L1 expression ≥50%, receiving first line pembrolizumab. We also evaluated a control cohort of metastatic NSCLC patients treated with first line platinum-based chemotherapy. Normal weight was set as control group.Results962 patients and 426 patients were included in the pembrolizumab and chemotherapy cohorts, respectively. Obese patients had a significantly higher objective response rate (ORR) (OR=1.61 (95% CI: 1.04–2.50)) in the pembrolizumab cohort, while overweight patients had a significantly lower ORR (OR=0.59 (95% CI: 0.37–0.92)) within the chemotherapy cohort. Obese patients had a significantly longer progression-free survival (PFS) (HR=0.61 (95% CI: 0.45–0.82)) in the pembrolizumab cohort. Conversely, they had a significantly shorter PFS in the chemotherapy cohort (HR=1.27 (95% CI: 1.01–1.60)). Obese patients had a significantly longer overall survival (OS) within the pembrolizumab cohort (HR=0.70 (95% CI: 0.49–0.99)), while no significant differences according to baseline BMI were found in the chemotherapy cohort. BMI variation significantly affected ORR, PFS and OS in both the pembrolizumab and the chemotherapy cohorts.ConclusionsBaseline obesity is associated to significantly improved ORR, PFS and OS in metastatic NSCLC patients with a PD-L1 expression of ≥50%, receiving first line pembrolizumab, but not among patients treated with chemotherapy. BMI variation is also significantly related to clinical outcomes.
Subject
Cancer Research,Pharmacology,Oncology,Molecular Medicine,Immunology,Immunology and Allergy
Cited by
67 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
|
|