Abstract
Mixed connective tissue disease (MCTD) is a complex overlap disease with features of different autoimmune connective tissue diseases (CTDs) namely systemic sclerosis, poly/dermatomyositis and systemic lupus erythematous in patients with antibodies targeting the U1 small nuclear ribonucleoprotein particle. In this narrative review, we summarise the results of a systematic literature research which was performed as part of the European Reference Network on Rare and Complex Connective Tissue and Musculoskeletal Diseases project, aimed at evaluating existing clinical practice guidelines (CPGs) or recommendations. Since no specific CPGs on MCTD were found, other CPGs developed for other CTDs were taken into consideration in order to discuss what can be applied to MCTD even if designed for other diseases. Three major objectives were proposed for the future development of CPGs: MCTD diagnosis (diagnostic criteria), MCTD initial and follow-up evaluations, MCTD treatment. Early diagnosis, epidemiological data, assessment of burden of disease and QOL aspects are among the unmet needs identified by patients.
Subject
Immunology,Immunology and Allergy,Rheumatology
Reference17 articles.
1. Mixed connective tissue disease-an apparently distinct rheumatic disease syndrome associated with a specific antibody to an extractable nuclear antigen (ENA)
2. Institute of Medicine (US) Committee to Advise the Public Health Service on Clinical Practice Guidelines . In: Field MJ , Lohr KN , eds. Clinical practice guidelines: directions for a new program. Washington (DC): National Academies Press (US), 1990.
3. Institute of Medicine (US) Committee on Standards for Developing Trustworthy Clinical Practice Guidelines . In: Graham R , Mancher M , Miller Wolman D , eds. Clinical practice guidelines we can trust. Washington (DC): National Academies Press (US), 2011.
4. AGREE II: advancing guideline development, reporting and evaluation in health care
5. Development of the AGREE II, part 1: performance, usefulness and areas for improvement
Cited by
30 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献