1. Despite these criticisms, a prospective study partially supports the original observations. Alderman et al carried out renin sodium profiling on 1717 hypertensive subjects identified by worksite screening.25 Subjects were followed for a mean of 8&3 years. The incidence of myocardial infarction per 1000 person-years was 14-7 in high renin hypertensive subjects, 5-6 in normal renin hypertensive subjects, and 2-8 in low renin hypertensive patients. The risk ratio for high versus low renin hypertension was 5-3;of, B blockers, all
2. Essential hypertension: renin and aldosterone, heart attack and stroke;Brunner, H.R.; Laragh, J.H.; Baer, L.; Newton, M.A.; Goodwin, F.T.; Krakoff, L.R.;N EnglJ Med,1972
3. A vascular permeability factor of renal origin;Asscher, A.W.; Anson, S.G.;Nature,1963
4. Studies on the identity of a vascular permeability factor of renal origin;Cuthbert, M.F.; Peart, W.S.;Clin Sci,1970
5. How an acute rise in arterial pressure damages arterioles. Electron microscopic changes during angiotensin infusion;Goldby, F.S.; Beilin, W.;Cardiovasc Res,1972