Receptor expression in synovial fluid neutrophils from patients with rheumatoid arthritis.

Author:

Watson F,Robinson J J,Phelan M,Bucknall R C,Edwards S W

Publisher

BMJ

Subject

General Biochemistry, Genetics and Molecular Biology,Immunology,Immunology and Allergy,Rheumatology

Reference28 articles.

1. Direct activation of neutrophil chemiluminescence by rheumatoid sera and synovial fluid;Gale, R.; V, Bertouch J.; Bradley, J.; J, Roberts-Thomson R.;Ann Rheum Dis; indicates that monoclonal antibody binding is 'blocked' by ligands (e.g. immune,1983

2. The primed neutrophil - a friend or foe in inflammation. Linkoping University Medical Dissertations present within the synovial fluid. Such ligand binding may also account, in part, for the decreased staining of CD16, but this receptor (and 3 1D8) is also shed from the plasma membrane during activation (fig 1) and this process may contribute to the decreased expression. Upregulation of CD 1 lb in synovial fluid neutrophils is indicative of priming or activation, or both. The observation that a short incubation of primed or unprimed bloodstream neutrophils with cell free synovial fluid induces these patterns of receptor expression indicates that these changes in receptor expression can occur rapidly as newly recruited No 335;Follin, P.,1991

3. Oxygen free radicals, inflammation and synovitis: the current status;Merry, P.; G, Winyard P.; J, Morris C.; Grootveld, M.; R, Blake D.;Ann Rheum Dis,1989

4. Neutrophils isolated from the synovial fluid of patients with rheumatoid arthritis: priming and activation in vivo;L, Nurcombe H.; C, Bucknall R.; W, Edwards S.;Ann Rheum Dis,1991

5. Human neutrophils increase expression of C3bi as well as C3b receptors upon activation;Berger, M.; O'Shea, J.; S, Cross A.;J Clin Invest,1984

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