Abnormalities in the regulation of variable region genes that encode for antibodies to DNA may be a central factor in the pathogenesis of systemic lupus erythematosus.

Author:

Singh A K

Publisher

BMJ

Subject

General Biochemistry, Genetics and Molecular Biology,Immunology,Immunology and Allergy,Rheumatology

Reference75 articles.

1. Pankewycz 0 G. Murine monoclonal anti-DNA antibodies bind directly to glomerular antigens and form immune deposits;P, Madaio M.; J, Carlson; J, Cataldo; A, Ucci; P, Migliorini;Immunol,1987

2. Restricted subpopulations of DNA antibodies in kidneys of mice with systemic lupus: comparison of antibodies in serum and renal eluates;M, Ebling F.; H, Hahn B.;Arthritis Rheum,1980

3. Monoclonal anti-DNA antibodies derived from lupus-prone mice form immune deposits at distinct glomerular locations andinduce different structural and functional abnormalities in vivo;V, Vlahakos D.; H, Foster M.; S, Adams;Kidney Int,1992

4. Anti-DNA antibodies bind directly to renal antigens and induce kidney dysfunction in the isolated perfused rat kidney;Raz, E.; Brezis, M.; Rosenmann, E.; Eilat, D.;J Immunol,1989

5. Polyreactive autoantibodies are nephritogenic in murine lupus nephritis;Pankewycz 0 G, Migliorini P, Madaio M P;JImmunol,1987

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