Neonatal screening for congenital hypothyroidism in Mexico: experience, obstacles, and strategies

Abstract

Objective To report the experience, obstacles, and strategies of screening for congenital hypothyroidism. Setting Newborns in Mexico. Methods Thyroid stimulating hormone (TSH) was measured by enzyme immunoassay using commercial kits in 1 140 364 newborns. Results There were 464 positive cases, of whom 299 (64.4%) were girls. 236 (50.9% showed ectopic nodules, 202 (43.5%) thyroid agenesis, 21 (4.5%) dyshormonogenesis, and 5 (1.1%) an unclassified goitre. The false positive rate was 0.024% and there were 11 false negative results. Currently, 600 000 (26%) of the 2 300 000 newborns are screened. This percentage has been increased in recent years by taking samples from cord blood and will be increased further by starting congenital hypothyroidism screening at social security units and by midwives screening infants born at home. Conclusions Mental retardation in infants in developing countries can be reduced by neonatal screening, and carefully planned strategies can steadily extend the benefits of screening.