Causes of death in children with congenital anomalies up to age 10 in eight European countries
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Published:2023-06
Issue:1
Volume:7
Page:e001617
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ISSN:2399-9772
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Container-title:BMJ Paediatrics Open
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language:en
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Short-container-title:bmjpo
Author:
Rissmann AnkeORCID, Tan JoachimORCID, Glinianaia Svetlana V, Rankin Judith, Pierini Anna, Santoro Michele, Coi Alessio, Garne Ester, Loane Maria, Given Joanne, Reid Abigail, Aizpurua Amaia, Akhmedzhanova Diana, Ballardini Elisa, Barisic IngeborgORCID, Cavero-Carbonell ClaraORCID, de Walle Hermien E K, Gatt Miriam, Gissler Mika, Heino Anna, Jordan Sue, Urhoj Stine KjaerORCID, Klungsøyr Kari, Lutke Renee, Mokoroa Olatz, Neville Amanda Julie, Thayer Daniel S, Wellesley Diana G, Yevtushok Lyubov, Zurriaga Oscar, Morris JoanORCID
Abstract
BackgroundCongenital anomalies (CAs) increase the risk of death during infancy and childhood. This study aimed to evaluate the accuracy of using death certificates to estimate the burden of CAs on mortality for children under 10 years old.MethodsChildren born alive with a major CA between 1 January 1995 and 31 December 2014, from 13 population-based European CA registries were linked to mortality records up to their 10th birthday or 31 December 2015, whichever was earlier.ResultsIn total 4199 neonatal, 2100 postneonatal and 1087 deaths in children aged 1–9 years were reported. The underlying cause of death was a CA in 71% (95% CI 64% to 78%) of neonatal and 68% (95% CI 61% to 74%) of postneonatal infant deaths. For neonatal deaths the proportions varied by registry from 45% to 89% and by anomaly from 53% for Down syndrome to 94% for tetralogy of Fallot. In children aged 1–9, 49% (95% CI 42% to 57%) were attributed to a CA. Comparing mortality in children with anomalies to population mortality predicts that over 90% of all deaths at all ages are attributable to the anomalies. The specific CA was often not reported on the death certificate, even for lethal anomalies such as trisomy 13 (only 80% included the code for trisomy 13).ConclusionsData on the underlying cause of death from death certificates alone are not sufficient to evaluate the burden of CAs on infant and childhood mortality across countries and over time. Linked data from CA registries and death certificates are necessary for obtaining accurate estimates.
Subject
Pediatrics, Perinatology and Child Health
Reference30 articles.
1. Global, regional, national, and selected subnational levels of stillbirths, neonatal, infant, and under-5 mortality, 1980–2015: a systematic analysis for the Global Burden of Disease Study 2015 2. Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010 3. European trends in mortality in children with congenital anomalies: 2000–2015;Pitt;Birth Defects Res,2021 4. Deaths: leading causes for 2017;Heron;Natl Vital Stat Rep,2019 5. Khan SQ , Berrington de Gonzalez A , Best AF , et al . Infant and youth mortality trends by race/ethnicity and cause of death in the United States. JAMA Pediatr 2018;172:e183317. doi:10.1001/jamapediatrics.2018.3317
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