Prevalence of microcephaly: the Latin American Network of Congenital Malformations 2010–2017

Author:

Morris JoanORCID,Orioli Ieda M,Benavides-Lara AdrianaORCID,de la Paz Barboza-Arguello María,Tapia Maria Aurora Canessa,de França Giovanny Vinícius Araújo,Groisman Boris,Holguin Jorge,Hurtado-Villa Paula Margarita,Ibarra Ramirez Marisol,Mellado Cecilia,Pardo Rosa,Pastora Bucardo Dania Maria,Rodríguez Catherin,Zarante Ignacio,Limb Elizabeth,Dolk Helen

Abstract

ObjectiveThe Latin American Network of Congenital Malformations: ReLAMC was established in 2017 to provide accurate congenital anomaly surveillance. This study used data from ReLAMC registries to quantify the prevalence of microcephaly from 2010 to 2017 (before, during and after the Zika virus epidemic).DesignNine ReLAMC congenital anomaly registries provided case-level data or aggregate data for any live births, still births or terminations of pregnancy with microcephaly. Births to pregnant women infected with Zika virus first occurred in Brazil in 2015, and in the remaining registry areas in 2016 with the exception of Chile that did not experience Zika virus. Therefore the prevalence of microcephaly for 2010–2014 and individual years 2015, 2016 and 2017 was estimated using multilevel random effect Poisson models. Clinical classification and characteristics of the cases were compared pre and post Zika for all centres providing individual case-level data.ResultsThe prevalence of microcephaly for all registries excluding Brazil was 2.3 per 10 000 (95% CI 2.0 to 2.6) for 2010–2014 rising to 5.4 (95% CI 4.8 to 6.0) in 2016 and 5.9 (95% CI 5.3 to 6.6) in 2017. Brazil had a prevalence of 0.6 per 10 000 (95% CI 0.5 to 0.6) in 2010–2014, rising to 5.8 (95% CI 5.6 to 6.1) in 2015, 8.0 (95% CI 7.6 to 8.3) in 2016 and then falling in 2017. Only 29 out of 687 cases of microcephaly were reported as congenital Zika syndrome in countries excluding Brazil.ConclusionsThe prevalence of microcephaly was influenced both by Zika causing congenital Zika syndrome and by increased reporting awareness.

Funder

European Union

Publisher

BMJ

Subject

Pediatrics, Perinatology and Child Health

Reference21 articles.

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4. Increase in Reported Prevalence of Microcephaly in Infants Born to Women Living in Areas with Confirmed Zika Virus Transmission During the First Trimester of Pregnancy — Brazil, 2015

5. Raised frequency of microcephaly related to Zika virus infection in two birth defects surveillance systems in Bogotá and Cali, Colombia;Hurtado-Villa;Pediatr Infect Dis J,2017

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