Author:
Scott Rachel M,Henske Elizabeth P,Raby Benjamin,Boone Philip M,Rusk Rosemary A,Marciniak Stefan J
Abstract
One in 10 patients suffering from primary spontaneous pneumothoraces has a family history of the disorder. Such familial pneumothoraces can occur in isolation, but can also be the presentation of serious genetic disorders with life-threatening vascular or cancerous complications. As the pneumothorax frequently precedes the more dangerous complications by many years, it provides an opportunity to intervene in a focused manner, permitting the practice of precision medicine. In this review, we will discuss the clinical manifestations and underlying biology of the genetic causes of familial pneumothorax.
Subject
Pulmonary and Respiratory Medicine
Cited by
27 articles.
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