1. Credle 1974'
2. Pereira 1978'
3. Dreison 1978'
4. Simpson 1986'
5. The dose requirements for midazolam differ between the sexes, males requiring about 1 mg more than females.24 There is a strong association between dose requirement and age; elderly patients are particularly sensitive to midazolam,782526 and extreme caution is recommended with its use in the elderly.' Like other benzodiazepines, midazolam causes respiratory depression. With low doses the decreased tidal volume is compensated for by an increased respiratory rate27; with larger doses this compensation mechanism is lost and hypoxaemia or apnoea may occur.' 2