Sex and gender reporting in UK emergency medicine trials from 2010 to 2023: a systematic review

Author:

Astin-Chamberlain RaineORCID,Pott JasonORCID,Cole ElaineORCID,Bloom Benjamin MichaelORCID

Abstract

BackgroundFemale participants are underrepresented in randomised control trials conducted in urgent care settings. Although sex and gender are frequently reported within demographic data, it is less common for primary outcomes to be disaggregated by sex or gender. The aim of this review is to report sex and gender of participants in the primary papers published on research listed on the National Institute of Health and Care Research (NIHR) Trauma and Emergency Care (TEC) portfolio and how these data are presented.MethodsThis is a systematic review of the published outputs of interventional trials conducted in UK EDs. Interventional trials were eligible to be included in the review if they were registered on the NIHR TEC research portfolio from January 2010, if the primary paper was published before 31 December 2023 and if the research was delivered primarily in the ED. Trials were identified through the NIHR open data platform and the primary papers were identified through specific searches using MedLine, EMBASE and PubMed. The primary objective of the review is to quantify the proportion of sex-disaggregated or gender-disaggregated primary outcomes in clinical trials within UK emergency medicine.ResultsThe initial search revealed 169 registered research projects on the NIHR TEC portfolio during the study period, of which 24 met the inclusion criteria. Overall, 76 719 participants were included, of which 31 374 (40%) were female. Only one trial (CRYOSTAT-2) reported a sex-disaggregated analysis of the effect of the intervention on either primary or secondary outcomes, and no sex-based difference in treatment effect was detected.ConclusionsFewer females than males were included in TEC trials from 2010 to 2023. One trial reported the primary outcome stratified by sex. There is significant scope to increase the scientific value of TEC trials to females by funders.

Publisher

BMJ

Reference35 articles.

1. The emerging science of gender-specific emergency medicine;McGregor;R I Med J (2013),2015

2. Doubly blind: a systematic review of gender in randomised controlled trials;Phillips;Glob Health Action,2016

3. Use of tranexamic acid in major trauma: a sex-disaggregated analysis of the Clinical Randomisation of an Antifibrinolytic in Significant Haemorrhage (CRASH-2 and CRASH-3) trials and UK trauma registry (Trauma and Audit Research Network) data;Nutbeam;Br J Anaesth,2022

4. Lynn Lieberman Lawry . We can only fix what we know about – why sex-disaggregated data in pharmaceutical systems is crucial. 2022. Available: https://www.mtapsprogram.org/news-blog/we-can-only-fix-what-we-know-about-why-sex-disaggregated-data-in-pharmaceutical-systems-is-crucial/ [Accessed 23 Jul 2024].

5. Van Epps H , Astudillo O , Del Pozo Martin Y , et al . The Sex and Gender Equity in Research (SAGER) guidelines: Implementation and checklist development. ESE 2022;48. doi:10.3897/ese.2022.e86910

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3