Abstract
Abstract
Objective
To prospectively assess the association of habitual glucosamine use with risk of cardiovascular disease (CVD) events.
Design
Prospective cohort study.
Setting
UK Biobank.
Participants
466 039 participants without CVD at baseline who completed a questionnaire on supplement use, which included glucosamine. These participants were enrolled from 2006 to 2010 and were followed up to 2016.
Main outcome measures
Incident CVD events, including CVD death, coronary heart disease, and stroke.
Results
During a median follow-up of seven years, there were 10 204 incident CVD events, 3060 CVD deaths, 5745 coronary heart disease events, and 3263 stroke events. After adjustment for age, sex, body mass index, race, lifestyle factors, dietary intakes, drug use, and other supplement use, glucosamine use was associated with a significantly lower risk of total CVD events (hazard ratio 0.85, 95% confidence interval 0.80 to 0.90), CVD death (0.78, 0.70 to 0.87), coronary heart disease (0.82, 0.76 to 0.88), and stroke (0.91, 0.83 to 1.00).
Conclusion
Habitual use of glucosamine supplement to relieve osteoarthritis pain might also be related to lower risks of CVD events.