Abstract
Purpose
To report 15-year incidence rate and associated risk factors of pterygium
among people aged 30 years and above at baseline in the rural clusters of
longitudinal Andhra Pradesh Eye Disease Study (APEDS III).
Methods
The baseline APEDS I included 7771 participants of which 6447 (83%) were
traced and 5395 (83.7%) were re-examined in APEDS III. To estimate the
incidence of pterygium, we selected participants who were 30 years and above at
baseline (4188), of which 2976 were traced and 2627 (88.3%) were examined, and
based on inclusion criteria, 2290 participants were included in the study. The
incidence rate of pterygium was defined as the proportion of people free of
pterygium at baseline who had developed the condition at 15-year follow-up
(range 13–17 years). Univariate and multivariable analyses for risk factors
were undertaken.
Results
The sex-adjusted incidence rate of pterygium was 25.2 per 100 person-years
(95% CI 24.8 to 25.7) which was significantly higher for men than women (26.3
per 100 person-years (95% CI 25.6 to 27.0) and 24.7 (95% CI 24.1 to 25.3)
respectively). At the multivariable analysis, male gender (RR: 1.35, 95% CI 1.0
to 1.83), no formal education (RR: 2.46, 95% CI 1.22 to 4.93), outdoor
occupation (RR: 1.47, 95% CI 1.14 to 1.9) and lower body mass index (BMI)
(<18.5) (RR: 1.25, 95% CI 1.02 to 1.55) were associated with increased risk
of pterygium.
Conclusions
The overall incidence rate of pterygium was high in this rural population,
especially in men and those engaged in outdoor activities, lack of formal
education and with lower BMI. It is likely that greater exposure to ultraviolet
light is a major contributing factor, thus warranting preventive
strategies.
Funder
Lions Clubs
International Foundation SightFirst
Subject
Cellular and Molecular Neuroscience,Sensory Systems,Ophthalmology
Cited by
6 articles.
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