Abstract
PurposeTo investigate the association of self-reported cataract surgery with all-cause and cause-specific mortality using a large-scale population-based sample.MethodsData from the 1999–2008 cycles of the National Health and Nutrition Examination Survey were used. A self-reported history of cataract surgery was considered a surrogate for the presence of clinically significant cataract surgery. Mortality data were ascertained from National Death Index records. Hazard ratios (HRs) and 95% confidence intervals (CIs) for survival were estimated using Cox proportional hazards regression models.ResultsA total of 14 918 participants were included in the analysis. During a median follow-up of 10.8 (Interquartile range, IQR, 8.25–13.7) years, 3966 (19.1%) participants died. Participants with self-reported cataract surgery were more likely to die from all causes and specific causes (vascular disease, cancer, accident, Alzheimer’s disease, respiratory disease, renal disease and others) compared with those without (all Ps <0.05). The association between self-reported cataract surgery and all-cause mortality remained significant after multiple adjustments (HR=1.13; 95% CI 1.01 to 1.26). For cause-specific mortality, multivariable Cox models showed that self-reported cataract surgery predicted a 36% higher risk of vascular-related mortality (HR=1.36; 95% CI 1.01 to 1.82). The association with other specific causes of mortality did not reach statistical significance after multiple adjustments.ConclusionsThis study found significant associations of self-reported cataract surgery with all-cause and vascular mortalities. Our findings provide potential insights into the pathogenic pathways underlying cataract.
Funder
CERA Foundation
Science and Technology Program of Guangzhou, China
Fundamental Research Funds of the State Key Laboratory of Ophthalmology
University of Melbourne at Research Accelerator Program
Project of Investigation on Health Status of Employees in Financial Industry in Guangzhou, China
National Natural Science Foundation of China
Research Foundation of Medical Science and Technology of Guangdong Province
Subject
Cellular and Molecular Neuroscience,Sensory Systems,Ophthalmology
Cited by
4 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献