Modulation of histamine-induced bronchoconstriction with inhaled, oral, and intravenous clemastine in normal and asthmatic subjects.

Author:

Hartmann V,Magnussen H,Holle J P,Schuler E

Publisher

BMJ

Subject

Pulmonary and Respiratory Medicine

Reference9 articles.

1. Neurohumoral interaction in airways;Gold, W.G.;Aml Rev Respir Dis,1977

2. Antihistamines;Goth, A.,1978

3. Inhaled antihistamines-bronchoreceptor sensitivity to histamine by clemastine or differences in drug absorption and tissue concentration of both the agonist and the antagonist. Whatever the explanation, the difference in response dilatation and effects on histamineand metacholineinduced bronchoconstriction;Nogrady, S.G.; Bevan, C.;Tlhorax,1978

4. Effect of an inhaled antihistamine (clemastine) as a bronchodilator and as a maintenance treatment in asthma. Thorax 1979; 34: to histamine with low concentrations of clemastine between normal and asthmatic subjects remains an interesting observation. Intravenous and oral medication, the latter to a lesser degree, caused disturbing sedation or drowsiness whereas no side-effects were reported after inhalation of the drug. Furthermore an attempt to improve the efficacy of oral clemastine by dosage increment would lead to increased and ultimately intolerable side-effects as already pointed out for other antihistamines by Schild et al.18 It is therefore clear that the clinical use of both intravenous and;Partridge, M.N.; Saunders, K.B.

5. Laboratory and clinical investigations of the antihistamine clemastine (Tavegy 1);Kallos, P.;Clin Trials J,1971

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