Effect of prolonged microcirculation time after thrombectomy on the outcome of acute stroke

Author:

Ji YachenORCID,Shi Bin,Yuan Quan,Wu Kangfei,Fang Jia,Wang Hao,Miao Zhuang,Sun Yi,Huang XianjunORCID,Zhou Zhiming

Abstract

BackgroundAlthough recanalization can be successful, microcirculatory dysfunction is common in acute large vessel occlusive stroke (LVOS). We assessed the microcirculation time by postprocessing software and analyzed its impact on prognosis in patients treated with mechanical thrombectomy (MT).MethodsPatients with acute LVOS treated with MT were retrospectively enrolled consecutively. We measured the time to peak (TTP) and cerebral circulation time (CCT) in regions of interest on digital subtraction angiography using syngo iFlow software (Siemens Healthineers, Forchheim, Germany). A modified Rankin score ≤2 at 90 days was defined as a favorable outcome. Logistic regression was used to analyze the effect of each time parameter on prognosis. Then, we included time parameters in the baseline model to construct receiver operating characteristic (ROC) curves to assess the predictive ability for prognosis.ResultsA total of 215 patients were finally included. Of them, 118 (54.9%) had a favourable outcome at 90 days. Multivariate analysis showed that the microvascular cerebral circulation time (mCCT) was significantly associated with poor outcomes (odds ratio (OR) 2.061, 95% confidence interval (CI) 1.414 to 3.005 p<0.001). The area under the ROC curve was significantly enhanced by including mCCT in the baseline model (0.859 vs 0.829, p=0.016, DeLong test).ConclusionsThe mCCT immediately after recanalization is a powerful predictive factor for 90-day functional prognosis.

Funder

the Scientific Research Fund Project for Talent Introduction of Yijishan Hospital, Wannan Medical College in China

the Natural Science Research Projects in Anhui Universities

Publisher

BMJ

Subject

Neurology (clinical),General Medicine,Surgery

Reference30 articles.

1. Prolonged cerebral circulation time is more associated with symptomatic carotid stenosis than stenosis degree or collateral circulation

2. Prediction of hyperperfusion phenomenon after carotid artery stenting and carotid angioplasty using quantitative DSA with cerebral circulation time imaging

3. Cerebral circulation time is a potential predictor of disabling ischemic cerebrovascular events in patients with Non-disabling middle cerebral artery stenosis;Chen;Front Neurol,2021

4. A radiologic study of the brain circulation by rapid serial angiography of the carotid artery;Greitz;Acta Radiol Suppl,1956

5. Cerebral circulation time after thrombectomy: a potential predictor of outcome after recanalization in acute stroke;Wang;J Am Heart Assoc,2022

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