A detailed morphologic and immunohistochemical comparison of pre- and postmenopausal endometriosis

Author:

Cumiskey J,Whyte P,Kelehan P,Gibbons D

Abstract

Background:Endometriosis depends on oestrogenic stimulation for its continued growth, accounting for its prevalence during reproductive years. There is doubt among clinicians regarding its existence in postmenopausal women in the absence of exogenous or endogenous sex hormones. We postulated that endometriosis occurring in postmenopausal women would show a different morphologic and immunohistochemical profile to the disease occurring in premenopausal women.Methods:We reviewed the most recent 100 cases of endometriosis in our department plus all cases occurring in women aged ⩾50 dating back to 1999. Cases were divided into <50 (n = 91), 50–59 (8) and ⩾60 (6), and analysed for extent of disease, proportions of epithelium and stroma, and amount of haemorrhage. Immunohistochemistry for oestrogen receptor (OR), progesterone receptor (PR) and CD10 was performed and analysed on all cases aged ⩾50 and on controls <50.Results:There was statistically less disease in older women when cases occurring in the cervix and in scars were excluded (p = 0.0191). There was no statistical difference in the proportions of epithelium or stroma, but there was a statistical difference in the amount of haemorrhage (p = 0.0154) with older women showing less haemorrhage. There was no significant difference in immunohistochemical profile.Conclusions:Endometriosis does occur in postmenopausal women but is less common, is present in smaller volumes, and is less active. It has the same immunohistochemical profile as the disease occurring in premenopausal women and we infer from this that it has the potential to reactivate given the appropriate stimulation.

Publisher

BMJ

Subject

General Medicine,Pathology and Forensic Medicine

Reference14 articles.

1. Robboy SJ Anderson MC Russell P . Endometriosis. In: Robboy SJ Anderson MC Russell P , eds. Pathology of the female reproductive tract. London, UK: Churchill Livingstone, 2002.

2. Shaw RW . Endometriosis. In: Shaw RW Soutter P Stanton SL , eds. Gynaecology. New York, USA: Churchill Livingstone, 1992.

3. CD10 is a sensitive and diagnostically useful immunohistochemical marker of normal endometrial stroma and of endometrial stromal neoplasms

4. CD10 is a marker for normal and neoplastic endometrial stromal cells.;Toki;Int J Gynecol Pathol,2002

5. CD10 is useful in demonstrating endometrial stroma at ectopic sites and in confirming a diagnosis of endometriosis.;Sumathi;J Clin Pathol,2002

Cited by 27 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3