1. In this prospectively studied cohort of low birthweight children, we found no evidence to support any association between premature labour and maternal airway hyper-responsiveness (and by implication, uterine smooth muscle responsiveness). Moreover, although a family history of asthma was more common in children with increased airway responsiveness, suggesting a familial component in airway responsiveness, this applied to both low birthweight children and to the reference group. The differences between our study and previous observations require explanation
2. The work was supported by the Spastics Society, Fisons Pharmaceuticals Ltd, and Glaxo UK Ltd
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