Anti-ubiquitin immunocytochemistry is more sensitive than conventional techniques in the detection of diffuse Lewy body disease.

Author:

Lennox G,Lowe J,Morrell K,Landon M,Mayer R J

Publisher

BMJ

Subject

Psychiatry and Mental health,Neurology (clinical),Surgery

Reference9 articles.

1. Clinical and pathological features of diffuse cortical Lewy body disease (Lewy body dementia);Gibb, W.R.G.; Esiri, M.M.; Lees, A.J.;Brain,1987

2. Dementia achieved with anti-ubiquitin immunocytochemistry and Parkinson's disease associated with diffuse cortical makes this easy. Secondly, H & E stains fail to stain Lewy bodies;Byrne, E.J.; Lowe, J.; Godwin-Austen, R.B.;Lancet,1987

3. Lewy bodies in cerebral cortex. Report of three cases;Kosaka, K.;Acta Neuropathol (Berl.),1978

4. The Lewy body in Parkinson's disease;Forno, L.S.;Adv Neurol,1986

5. Diffuse Lewy accessible to antibody (whether because ubiquitin is a body disease. Neuropathological and biochemical smaller molecule, present in larger amounts, or located studies of six patients. Acta Neuropathol. (Berl.) more superficially) than other epitopes such as those of neurofilament. Fourthly, it is possible, although not proven by this study, that anti-ubiquitin immunocytochemistry is revealing a subset of inclusion bodies which are not visualised using conventional stains. This is certainly so when the technique is applied to cases of motor neuron disease, where anti-ubiquitin;Dickson, D.W.; Davies, P.; Mayeux, R.,1987

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