1. Multiply resistant class A pathogen, is considered insensitive to chloramphenicol treatment.25 The MIC90 for Pneumococcus causing meningitis: its epidemiology within a 3 Abdraaym-csarSeMc, entDree.gLnaannceTt]1,98V1i; nici:ig7u7e1r-r3a. V. Marrow aplasia ofloxacin is 4 [tg/ml compared with 128 [tg/ml for chloramphenicol against P. aeruginosa." The following topical application of chloramphenicol eye ointment;Radetsky, M.S.; Istre, G.R.; Johansen, T.L.;Arch Intern Med,1980
2. The potential use of quinolones in Chloramphenicol resistance occurs in many pathogenic species, including H. influenzae and future ocular antimicrobial therapy;Borrmann, L.R.; Leopold, I.H.,1988
3. High frequencies of resistance, ranging from 30% to 58% of clinical isolates, bacterial activity ofofloxacin and its mode of action;Sato, K.; Inoue, Y.; Fujii, T.; Aoyama, H.; pneumoniae, Mitsuhashi S.Anti- S.;Infection,1986
4. The in-vitro activities of because plasmid-borne factors exist, and conjugative transfer of the plasmid occurs.29-3' In contrast, ofloxacin-resistant strains seldom arise, and the development of plasmid-borne enoxacin and ofloxacin compared with that of ciprofloxacin;King, A.; Shannon, K.; Phillips, I.;JAntimicrob Chemother,1985
5. Susceptibility in vitro of gram-positive aerobe and anaerobe bacteria to ofloxacin;Debbia, E.; Mannelli, S.; Gianrossi, G.; Schito, G.C.;DrugsExpClinRes,1987