Synthesis of the active metabolite of vitamin D, 1,25(OH)2D3, by synovial fluid macrophages in arthritic diseases.

Author:

Hayes M E,Denton J,Freemont A J,Mawer E B

Publisher

BMJ

Subject

General Biochemistry, Genetics and Molecular Biology,Immunology,Immunology and Allergy,Rheumatology

Reference22 articles.

1. This may result;R, M.; A, McCain T.;N Engl J Med; Basic and clinical concepts related from feedback regulation of renal 1,25(OH)2D3 to vitamin D metabolism and action,1977

2. 1,25-Dihydroxyvitamin DI receptors in lymphocytes from patients with rheumatoid arthritis;C, Manolagas S.; A, Werntz D.; D, Tsoukas C.; M, Provvedini D.; H, Vaughan J.;J Lab Clin Med; levels are abnormally high or the mass of,1986

3. 1,25-Dihydroxyvitamin D3 receptors in synovial cells in rheumatoid arthritis [Abstractl.';N, Sambrook P.; A, Eisman J.; S, Breit;Aust NZ J Med,1987

4. Vitamin D synovial fluid are lower than in serum (Mawer, metabolites in synovial fluid;Fairney, A.; M, Starffen A.; May, C.; H, Seifert M.;Ann Rheum Dis; unpublished observations), probably owing to the smaller concentration of vitamin D binding protein. The importance of 1,25(OH)2D3 production by,1987

5. Gammainterferon stimulates production of 1,25-dihydroxyvitamin D3 by normal human macrophages;P, Koeffler H.; H, Reichel; E, Bishop J.; W, Norman A.;Biochein Biophys Res Comnmun,1985

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