1. Positive serum samples were tested for antibodies to double stranded DNA by the Farr technique, Sm, RNP, SSA, and SSB.12 C3 and C4 were measured by nephelometry (Smith Kline Bio-Science Laboratories, Atlanta, Georgia). Circulating immune complexes were measured by '25I Clq binding and staphylococci binding assays carried out at the Center for Disease Control.'y'5 The normal range for Clq binding assay is less than 8% and for the staphylococci binding assay less than 25. The patients admitted to the study had clinical or background information indicating the possibility of a connective tissue disease. Of patients who entered the practice in 1982 and whose details were placed on computer in 1985, 4500 were available for analysis. Each patient had a comprehensive history and physical examination and appropriate laboratory
2. The anticentromere antibody: disease specificity and clinical significance;C, Powell F.; K, Winkelmann R.; F, Venencie-Lemarchand; L, Spurbeck J.; L, Schroeter A.,1984
3. Anticentromere antibody: an immunological marker of a subset of systemic sclerosis;P, Chorzelski T.; S, Jablonska; H, Beutner E.;Br J Dermatol,1985
4. cloned fusion protein CtermCENP-B[B-gal] as anti-Different antibody patterns and different prognoses in patients gen, one can now detect anticentromere antibody without using indirect immunofluorescence.t9 The presence of other antinuclear antibodies may interwith scleroderma with various extent of skin sclerosis;Giordano, M.; Valentini, G.; Migliaresi, S.; Picillo, U.; Vatti, M.;J Rheumatol,1986
5. The clinical significance of the anticentromere antibody. Br J fere with the identification of anticentromere anti-Rheumatol 1987; 26: 17-21. body by immunofluorescence. In this paper we were able to identify anticentromere antibody in patients despite the presence of other antinuclear antibodies