Abstract
Introduction
Deprescribing (medication dose reduction or
cessation) is an integral component of appropriate
prescribing. The extent to which deprescribing recommendations are
included in clinical practice guidelines is unclear. This scoping review
aimed to identify guidelines that contain deprescribing recommendations,
qualitatively explore the content and format of deprescribing
recommendations and estimate the proportion of guidelines that contain
deprescribing recommendations.
Methods
Bibliographic databases and Google were searched for guidelines
published in English from January 2012 to November 2022. Guideline
registries were searched from January 2017 to February 2023. Two
reviewers independently screened records from databases and Google for
guidelines containing one or more deprescribing recommendations. A 10%
sample of the guideline registries was screened to identify eligible
guidelines and estimate the proportion of guidelines containing a
deprescribing recommendation. Guideline and recommendation
characteristics were extracted and language features of deprescribing
recommendations including content, form, complexity and readability were
examined using a conventional content analysis and the SHeLL Health
Literacy Editor tool.
Results
80 guidelines containing 316 deprescribing recommendations were
included. Deprescribing recommendations had substantial variability in
their format and terminology. Most guidelines contained recommendations
regarding forwho(75%, n=60),
what(99%, n=89) andwhen or
why(91%, n=73) to deprescribe, however, fewer
guidelines (58%, n=46) contained detailed guidance
onhowto deprescribe. Approximately 29% of
guidelines identified from the registries sample (n=14/49) contained one
or more deprescribing recommendations.
Conclusions
Deprescribing recommendations are increasingly being incorporated
into guidelines, however, many guidelines do not contain clear and
actionable recommendations onhowto
deprescribe which may limit effective implementation in clinical
practice. A co-designed template or best practice guide, containing
information on aspects of deprescribing recommendations that are
essential or preferred by end-users should be developed and
employed.
Trial registration number
osf.io/fbex4.
Funder
Australian National Health and Medical Research
Council
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