1. *Barratt-Boyes and Wood (1958). tKennedy et al. (1966).
2. tSnell and Luchsinger;Gaasch;*Miller et al,1972
3. Acebutolol is a cardioselective beta-blocking drug with one-quarter to one-seventh the beta-blocking potency of propranolol;Waagstein et al; It also possesses intrinsic sympathomimetic activity. Hence it has similar pharmacological properties to alprenolol and practolol which were used by,1973
4. The dose of 25 mg was chosen because the haemodynamic response to 30 mg intravenously has been reported in normal subjects,1973
5. attributed much of the observed therapeutic benefit in their patients to a reduction of heart rate. They postulated that since left ventricular external work is equivalent to the product of heart rate and systolic blood pressure, a reduction in the former would reduce;Waagstein,1975