Inhibition of prostaglandin synthetase in human rectal mucosa.

Author:

Hawkey C J,Lo Casto M

Publisher

BMJ

Subject

Gastroenterology

Reference10 articles.

1. Prostaglandin synthetase activity in acute ulcerative colitis: effects of treatment with sulphasalazine. codeine phosphate and prednisolone;CHJ, Smith PR. Dawson DJ. Swan;Gut,1979

2. Youlten LJF. Rectal by human rectal mucosa but they do not appear to mucosal prostaglandin E, release and its relation to be effective agents in the treatment of ulcerative disease activity. electrical potential difference and colitis. "" A detailed analysis of treatment of active ulcerative colitis by flurbiprofen showed that this drug had a number of deleterious effects.';Rampton, D.S.; Sladen, G.E.,1980

3. Effect of prednisolone on prostaglandin synthesis by rectal mucosa in ulcerative colitis: investigation by laminar flow bioassav and radioimmunoassay;Hawkey, C.J.; Truelove, S.C.;Gut,1981

4. Evidence that prednisolone is inhibitorv to the cyclooxygenase activity of human rectal mucosa;Hawkey, C.J.;Prostaglandins,1982

5. These data show that, in some circumstances, sulphasalazine and 5-ASA might lead to enhanced rather than reduced levels of mucosal prostaglandins. There is at present, however, very little direct evidence that this would lead to a 'cyto-protective' effect in the sulphasalazine;Lancet,1977

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