The association of the slow acetylator phenotype with bladder cancer.

Author:

Evans D A,Eze L C,Whibley E J

Publisher

BMJ

Subject

Genetics (clinical),Genetics

Reference28 articles.

1. Suitable control information for the present bladder cancer patients has been obtained by pooling data which have previously been published on several series of Liverpool white British subjects,I)

2. control groups. Cartwright et a18 observed a strikingly high association between the slow acetylator phenotype and bladder cancer in Huddersfield dye workers. No such sub-group of occupational exposure could be defined in the present series where persons had been exposed to a wide variety ofindustrial chemicals. The association revealed in table 2 is clearly strengthened by the inclusion of the Huddersfield dye workers, but would still be statistically significant (p<0.05) if the data of Cartwright et a18 were omitted

3. Some illustrative systems of chemical carcinogenesis (2) aromatic amines;Manson, D.,1976

4. Genetic variation in N-acetylation of carcinogenic arylamines by human and rabbit liver;Glowinski, I.B.; Radtke, H.E.; Weber, W.W.;Mol Pharmacol,1978

5. Genetic regulation of aromatic amine N-acetylation in inbred mice;Glowinski, I.B.; Weber, W.W.;J Biol Chem,1982

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