On the ethical permissibility ofin situreperfusion in cardiac transplantation after the declaration of circulatory death

Author:

Kreitmair Karola VeronikaORCID

Abstract

Transplant surgeons in the USA have begun performing a novel organ procurement protocol in the setting of circulatory death. Unlike traditional donation after circulatory death (DCD) protocols,in situnormothermic perfusion DCD involves reperfusing organs, including the heart, while still contained in the donor body. Some commentators, including the American College of Physicians, have claimed thatin situreperfusion after circulatory death violates the widely accepted Dead Donor Rule (DDR) and conclude thatin situreperfusion is ethically impermissible. In this paper I argue that, in terms of respecting the DDR,in situreperfusion cardiac transplantation does not differ from traditional DCD cardiac transplantation. I do this by introducing and defending a refined conception of circulatory death, namelyvegetative state function permanentism. I also argue against the controversial brain occlusion feature of thein situreperfusion DCD protocol, on the basis that it is ethically unnecessary and generates the problematic appearance of ethical dubiousness.

Publisher

BMJ

Subject

Health Policy,Arts and Humanities (miscellaneous),Issues, ethics and legal aspects,Health (social science)

Reference49 articles.

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2. American College of Physicians . Ethics, Determination of Death, and Organ Transplantation in Normothermic Regional Perfusion (NRP) with Controlled Donation after Circulatory Determination of Death. cDCD: American College of Physicians Statement of Concern, 2021: 6.

3. The Dead Donor Rule and Organ Transplantation

4. Normothermic regional perfusion requires careful ethical analysis before adoption into donation after circulatory determination of death;Peled;Crit Care Med,2022

5. President’s Commission . Defining death: a report on the medical, legal and ethical issues in the determination of death. 1981. Available: https://scholarworks.iupui.edu/handle/1805/707 [Accessed 1 Feb 2022].

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1. Why We Still Need a Substantive Determination of Death;The American Journal of Bioethics;2023-01-22

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