The 2023 ACR/EULAR classification criteria for calcium pyrophosphate deposition disease
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Published:2023-07-26
Issue:10
Volume:82
Page:1248-1257
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ISSN:0003-4967
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Container-title:Annals of the Rheumatic Diseases
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language:en
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Short-container-title:Ann Rheum Dis
Author:
Abhishek AbhishekORCID, Tedeschi Sara KORCID, Pascart TristanORCID, Latourte AugustinORCID, Dalbeth NicolaORCID, Neogi TuhinaORCID, Fuller AmyORCID, Rosenthal Ann, Becce FabioORCID, Bardin ThomasORCID, Ea Hang-KorngORCID, Filippou GeorgiosORCID, Fitzgerald JohnORCID, Iagnocco AnnaMariaORCID, Lioté FrédéricORCID, McCarthy Geraldine MORCID, Ramonda RobertaORCID, Richette PascalORCID, Sivera Francisca, Andrés MarianoORCID, Cipolletta EdoardoORCID, Doherty Michael, Pascual EliseoORCID, Perez-Ruiz Fernando, So Alexander, Jansen Tim L, Kohler Minna J, Stamp Lisa KORCID, Yinh Janeth, Adinolfi Antonella, Arad UriORCID, Aung Thanda, Benillouche Eva, Bortoluzzi AlessandraORCID, Dau Jonathan, Maningding Ernest, Fang Meika A, Figus Fabiana A, Filippucci Emilio, Haslett Janine, Janssen Matthijs, Kaldas Marian, Kimoto Maryann, Leamy Kelly, Navarro Geraldine M, Sarzi-Puttini Piercarlo, Scirè CarloORCID, Silvagni Ettore, Sirotti SilviaORCID, Stack John R, Truong Linh, Xie Chen, Yokose ChioORCID, Hendry Alison M, Terkeltaub Robert, Taylor William J, Choi Hyon KORCID
Abstract
ObjectiveCalcium pyrophosphate deposition (CPPD) disease is prevalent and has diverse presentations, but there are no validated classification criteria for this symptomatic arthritis. The American College of Rheumatology (ACR) and EULAR have developed the first-ever validated classification criteria for symptomatic CPPD disease.MethodsSupported by the ACR and EULAR, a multinational group of investigators followed established methodology to develop these disease classification criteria. The group generated lists of candidate items and refined their definitions, collected de-identified patient profiles, evaluated strengths of associations between candidate items and CPPD disease, developed a classification criteria framework, and used multi-criterion decision analysis to define criteria weights and a classification threshold score. The criteria were validated in an independent cohort.ResultsAmong patients with joint pain, swelling, or tenderness (entry criterion) whose symptoms are not fully explained by an alternative disease (exclusion criterion), the presence of crowned dens syndrome or calcium pyrophosphate crystals in synovial fluid are sufficient to classify a patient as having CPPD disease. In the absence of these findings, a score>56 points using weighted criteria, comprising clinical features, associated metabolic disorders, and results of laboratory and imaging investigations, can be used to classify as CPPD disease. These criteria had a sensitivity of 92.2% and specificity of 87.9% in the derivation cohort (190 CPPD cases, 148 mimickers), whereas sensitivity was 99.2% and specificity was 92.5% in the validation cohort (251 CPPD cases, 162 mimickers).ConclusionThe 2023 ACR/EULAR CPPD disease classification criteria have excellent performance characteristics and will facilitate research in this field.
Subject
General Biochemistry, Genetics and Molecular Biology,Immunology,Immunology and Allergy,Rheumatology
Reference30 articles.
1. European League Against Rheumatism recommendations for calcium pyrophosphate deposition. Part I: terminology and diagnosis 2. Prevalence of musculoskeletal conditions in an Italian population sample: results of a regional community-based study. I. The MAPPING study;Salaffi;Clin Exp Rheumatol,2005 3. Prevalence of Chondrocalcinosis in Italian subjects from northeastern Italy. The pro.V.A. (Progetto Veneto Anziani) study;Ramonda;Clin Exp Rheumatol,2009 4. UK community prevalence of knee chondrocalcinosis: evidence that correlation with osteoarthritis is through a shared association with osteophyte 5. The prevalence of Chondrocalcinosis in the elderly and its association with knee osteoarthritis: the Framingham study;Felson;J Rheumatol,1989
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