Treatment of a patient with severe systemic sclerosis (SSc) using CD19-targeted CAR T cells

Author:

Bergmann ChristinaORCID,Müller FabianORCID,Distler Jörg H WORCID,Györfi Andrea-HerminaORCID,Völkl Simon,Aigner Michael,Kretschmann Sascha,Reimann Hannah,Harrer Thomas,Bayerl Nadine,Boeltz SebastianORCID,Wirsching Andreas,Taubmann Jule,Rösler Wolf,Spriewald Bernd,Wacker Jochen,Atzinger Armin,Uder Michael,Kuwert Torsten,Mackensen Andreas,Schett GeorgORCID

Funder

Deutsche Forschungsgemeinschaft

Deutsche Krebshilfe

IZKF Erlangen

German Federal Ministry of Education and Research

Publisher

BMJ

Subject

General Biochemistry, Genetics and Molecular Biology,Immunology,Immunology and Allergy,Rheumatology

Reference8 articles.

1. Altered blood B lymphocyte homeostasis in systemic sclerosis: Expanded naive B cells and diminished but activated memory B cells;Sato;Arthritis Rheumatol,2004

2. Safety and efficacy of Rituximab in systemic sclerosis (DESIRES): A double-blind, investigator-initiated, randomised, placebo-controlled trial;Ebata;The Lancet rheumatology,2021

3. Rituximab versus intravenous cyclophosphamide in patients with connective tissue disease-associated interstitial lung disease in the UK (RECITAL): A double-blind, double-dummy, randomised, controlled, phase 2B trial;Maher;Lancet (London, England),2023

4. Autologous Hematopoietic Stem Cell Transplantation vs Intravenous Pulse Cyclophosphamide in Diffuse Cutaneous Systemic Sclerosis

5. CD19-Targeted CAR T Cells in Refractory Systemic Lupus Erythematosus

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