Abstract
This study aimed to evaluate the association of ascending aortic diameter (AAD) measured by low-dose chest CT (LDCT) and metabolic syndrome (MS) in Korean men. AAD was measured with LDCT in 1046 healthy Korean men (mean age 50.7±9.7 years, range 28 to 69 years) participating in medical health check-up in a university health promotion center. AAD was defined as the longest length measured from the left main coronary ostium to the level of the right pulmonary artery in the axial plane in LDCT. The association between AAD and MS was examined using logistic regression. The mean of AAD was significantly higher in cases with MS (37.2±4.2 mm) compared with those without MS (35.1±4.3 mm) (p<0.001). Logistic regression with AAD showed that ORs and 95% CI of MS in Q2 (1.72, 95% CI 1.23 to 2.53), Q3 (2.59, 95% CI 1.85 to 5.81) and Q4 (4.71, 95% CI 1.63 to 8.79) were significantly higher compared with Q1 (the lowest quartile). In variable (age, body surface area, total cholesterol, alanine aminotransferase, gamma-glutamyl transferase, smoking, alcohol intake and exercise) adjusted multiple linear regression analysis, Q4 (the highest quartile of AAD) was significantly associated with MS compared with Q1 (OR 4.52, 95% CI 1.67 to 9.87). In conclusion, AAD measured by LDCT is significantly associated with the prevalence of MS in Korean men.
Subject
General Biochemistry, Genetics and Molecular Biology,General Medicine
Reference30 articles.
1. Aortic size assessment by noncontrast cardiac computed tomography: normal limits by age, gender, and body surface area;Wolak;JACC Cardiovasc Imaging,2008
2. Usefulness of aortic root dimension in persons > or = 65 years of age in predicting heart failure, stroke, cardiovascular mortality, all-cause mortality and acute myocardial infarction (from the Cardiovascular Health Study);Gardin;Am J Cardiol,2006
3. Connective tissue proteinases and inhibitors in abdominal aortic aneurysms. Involvement of the vasa vasorum in the pathogenesis of aortic aneurysms;Herron;Arterioscler Thromb,1991
4. Aortic root dimensions and stiffness in healthy subjects;Vriz;Am J Cardiol,2013
5. Definition of metabolic syndrome: report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition;Grundy;Arterioscler Thromb Vasc Biol,2004
Cited by
5 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献