Destructive bone lesions in primary amyloidosis.

Author:

Kramer M. R.,van Dijk J. M.,Hadas I.,Hershko C.

Publisher

BMJ

Subject

General Medicine

Reference25 articles.

1. Kyle & Griep (1983) Bernhard & Heusley (1969) Wahner et al. (1975) Weinfeld et al. (1970) Khojasteh et al. (1979)

2. The amyloid fibril has recently been identified with the variable region of the immunoglobulin light chain in both primary amyloidosis and amyloidosis complicating multiple myeloma. Despite this similarity in the molecular structure of amyloid, the clinical, radiological and laboratory features ofthe two clinical entities differ significantly. This is illustrated by the difference in the frequency and distribution ofdestructive bone lesions in the two conditions,1983

3. Skeletal lesions associated with primary amyloidosis may affect primarily the joints or the bones. Amyloid deposits in and around joints result in soft tissue swelling caused by capsular and pericapsular infiltration. The amyloid may fill the joint space and produce erosion of the articular surface. Clinically such patients suffer from painful swelling and stiffness of the involved joints. The most common sites are large joints such as the shoulders, hips and elbows,1970

4. Amyloidosis of bone - Report of two cases;AXELLSSON, U.; HALLEN, A.; RAUSING, A.;Journal of Bone and Joint Surgery,1970

5. Amyloid arthropathy;BERNHARD, G.S.; HEUSLEY, G.T.;Arthritis and Rheumatism,1969

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