Familial multiple sclerosis: MRI findings in clinically affected and unaffected siblings.

Author:

Tienari P J,Salonen O,Wikstrom J,Valanne L,Palo J

Publisher

BMJ

Subject

Psychiatry and Mental health,Clinical Neurology,Surgery

Reference33 articles.

1. Cerebrospinal fluid findings in healthy siblings of multiple sclerosis patients. Neurology 1986; 36: 727-29. age group under 50 Lynch et al found four asymptomatic subjects out of 24 who had;Duquette, P.; Charest, L.

2. Evoked potential testing in relatives of multiple sclerosis patients. Ann Neurol 1985; 18: 30-4. lesions, but none of these seemed to meet the criteria I used in our study;Nuwer, M.R.; Visscher, B.R.; Packwood, J.W.; Namerow, W.S.

3. Unsuspected multiple sclerosis;Gilbert, J.J.; Sadler, M.;Arch Neurol,1983

4. Atypical and clinically silent multiple Genetic susceptibility to MS has become a field of intensive research.5 The occurrence of subclinical disease among asymptomatic siblings of MS patients has a strong impact on genetic investigation. It is an important confounding factor in family studies resulting in sclerosis: a report of 12 cases discovered unexpectedly at necropsy;Phadke, J.G.; Best, P.V.;J Neurol Neurosurg Psychiatry,1983

5. McDonald WI. Diagnosis 1989;299:635-7.

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