1. Azathioprine and multiple sclerosis;WR, I.Swinburn; LA, Liversedge;J Neurol Neurosur Psychiatry,1973
2. Sir: In 1983 the Medical Research Council Working Party on Trials of Immunological Treatment in Multiple Sclerosis concluded that existing trials1 did not determine early in their disease (within 2 or 5 years of onset) will be analysed separately from those treated later. Patients with relatively mild disease at entry into the trial (Kurtzke disability status scale score less than 5) will be analysed separately from those with more thioprine in treatment of multiple sclerosis: final results of 4 year controlled study of its effectiveness covering 115 patients;J Neurol Sci,1982
3. Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS);Kurtzke, J.F.;Neurology; 33: whether azathioprine is effective in the treatsevere disease (scores 5-6). Of particular in,1983
4. embarked on a double-blind controlled multicentre trial of treatment with azathioprine lasting for three years. Between April 1983 and October 1984, 354 patients were randomly allocated to azathioprine or placebo effective in those patients who have a malignant disease course in whom scores of 5-6 have been achieved within five years from onset. Other aspects which merit investigation are possible differences in re-
5. Intensive immunosuppression in progressive multiple sclerosis. A randomised three-arm study of high-dose intravenous cyclophosphamide, plasma exchange and ACTH;N Engi J Med,1983