Abstract
ObjectiveTo establish the prevalence of hyperuricaemia in an elderly Finnish cohort and to assess its association with comorbidities and mortality.DesignProspective cohort study.SettingGood Ageing in Lahti Region study, Finland 2002–2012 (mortality data analysed until 2018).Participants2673 participants (mean age 64 years; 47% men).Primary and secondary outcome measuresPrevalence of hyperuricaemia in the study population was detected. Associations between hyperuricaemia and mortality were assessed using multivariable adjusted Cox proportional hazards models.MethodsData from a prospective, population-based study of elderly people (52–76 years) in the Lahti region, Finland, were used. Information on serum uric acid (SUA) levels as well as several other laboratory variables, comorbidities, lifestyle habits and socioeconomic factors was collected, and the association between SUA level and mortality in a 15-year follow-up period was analysed.ResultsOf 2673 elderly Finnish persons included in the study 1197 (48%) were hyperuricaemic. Hyperuricaemia was extremely prevalent in men (60%). There was an association between elevated SUA and mortality which remained after adjustment for potential confounding factors (age, gender, education, smoking status, body mass index, hypertension and dyslipidaemia). The adjusted HR for all-cause mortality among clearly hyperuricaemic individuals with SUA≥420 µmol/L compared with normouricaemic individuals (SUA<360 µmol/L) was 1.32 (95% CI 1.05 to 1.60) in women and 1.29 (95% CI 1.05 to 1.60) in men. In slightly hyperuricaemic individuals (SUA 360–420 µmol/L) the corresponding HRs were 1.03 (95% CI 0.78 to 1.35) and 1.11 (95% CI 0.89 to 1.39).ConclusionsHyperuricaemia is very prevalent in the elderly Finnish population and is independently associated with increased mortality.
Reference51 articles.
1. Update on the epidemiology, genetics, and therapeutic options of hyperuricemia;Li;Am J Transl Res,2020
2. The Daniel K. inouye College of pharmacy scripts: perspectives on the epidemiology of gout and hyperuricemia;Roman;Hawaii J Med Public Health,2019
3. Kumar A. U. A , Browne LD , Li X , et al . Temporal trends in hyperuricaemia in the Irish health system from 2006-2014: a cohort study. PLoS ONE 2018;13:e0198197. doi:10.1371/journal.pone.0198197
4. Increasing prevalence of gout and hyperuricemia over 10 years among older adults in a managed care population;Wallace;J Rheumatol,2004
5. Epidemiology of gout and hyperuricaemia in Italy during the years 2005–2009: a nationwide population-based study
Cited by
2 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献