Abstract
ObjectivesHyper-reflective outer retinal band (HORB) disruptions are reported across a range of retinal disease, yet a reliable, easily implemented assessment method and thorough evaluation of their association to retinal disease is lacking. The purpose of the study was to assess the reliability of using magnitude estimation to evaluate HORB length and determine its association to visual acuity and retinal disease.DesignCross-sectional, retrospective study.SettingPatients attending a secondary eye care clinic in Sydney, Australia.Participants2039 unique consecutive patients were screened for inclusion between 2 November and 18 January 2021, and 600 were included in the study population. Patients were included if they were referred from primary care, presented for an initial, comprehensive eye examination during the study period, imaged with optical coherence tomography during their visit and over 18 years of age.Primary outcomeReliability of HORB length estimations and associations to clinical outcomes.ResultsIntragrader (intraclass correlation coefficient, ICCfovea=0.81; ICCworst=0.91) and intergrader (ICCfovea=0.78–0.79; ICCworst=0.75–0.88) agreement of HORB length was good to excellent. HORB length was significantly associated with age (p<0.001, β=−0.22 to –0.24) and refractive error (p<0.001, β=0.12–0.16) at all B-scan locations. Visual acuity (p=0.001, β=−0.13) was associated with the primary outcome for foveal B-scans and eccentricity (p=0.002, β=−0.13) and device type (p=0.002, β=0.13) for non-foveal B-scans. Glaucoma was associated with HORB length on univariate analysis (p=0.05–0.06, β=−0.08); however, multivariate analysis revealed no significant association between HORB length and retinal disease.ConclusionHORB length is reliably assessed using magnitude estimation and may be useful as a surrogate biomarker of visual acuity. Several factors affect HORB length estimations, which may contribute to the lack of association to retinal disease and highlights the need for covariable adjustment when examining HORB disruptions.
Funder
National Health and Medical Research Council
Centre for Eye Health
Research Training Program
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献