Author:
Nwaru Bright I,Ekerljung Linda,Rådinger Madeleine,Bjerg Anders,Mincheva Roxana,Malmhäll Carina,Axelsson Malin,Wennergren Göran,Lotvall Jan,Lundbäck Bo
Abstract
PurposeThe West Sweden Asthma Study (WSAS) is a population-representative longitudinal study established to: (1) generate data on prevalence trends, incidence and remission of asthma, allergy and respiratory conditions, (2) elucidate on the risk and prognostic factors associated with these diseases, (3) characterise clinically relevant phenotypes of these diseases and (4) catalyse relevant mechanistic, genomic, genetic and translational investigations.ParticipantsWSAS comprised of randomly selected individuals aged 16 to 75 years who are followed up longitudinally. The first stage involved a questionnaire survey (>42 000 participants) and was undertaken in 2008 and 2016. A random sample (about 8000) of participants in the initial survey undergoes extensive clinical investigations every 8 to 10 years (first investigations in 2009 to 2012, second wave currently ongoing). Measurements undertaken at the clinical investigations involve structured interviews, self-completed questionnaire on personality traits, physical measurements and extensive biological samples.Findings to dateSome of our key findings have shown a 54% increase in the use of asthma medications between the 1990s and 2000s, primarily driven by a five-fold increase in the use of inhaled corticosteroids. About 36% of asthmatics expressed at least one sign of severe asthma indicator, with differential lung performance, inflammation and allergic sensitisation among asthmatics with different signs of severe asthma. Multi-symptom asthmatics were at greater risk of having indicators of severe asthma. In all adults, being raised on a farm was associated with a decreased risk of allergic sensitisation, rhinitis and eczema, but not asthma. However, among adolescents (ie, those 16 to 20 years of age), being raised on a farm decreased the risk of asthma. Personality traits were associated with both beliefs of asthma medication and adherence to treatment.Future plansFollow-up of the cohort is being undertaken every 8 to 10 years. The repeated clinical examinations will take place in 2019 to 2022. The cohort data are currently being linked to routine Swedish healthcare registers for a continuous follow-up. Mechanistic, genomic, genetic and translational investigations are ongoing.
Funder
Swedish Heart Lung Foundation
VBG Group Herman Krefting Foundation on Asthma and Allergy
Health authorities of the West Gothia Region
Swedish Research Council
Vårdal Foundation
Reference57 articles.
1. Disease and Injury Incidence and Prevalence Collaborators. Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries;GBD;Lancet,2015
2. Is asthma prevalence still increasing?;Lundbäck;Expert Rev Respir Med,2016
3. The problem of asthma worldwide;Woolcock;Eur Respir Rev,1991
4. Epidemiology of rhinitis and asthma;Lundbäck;Clin Exp Allergy,1998
5. 50 years of asthma: UK trends from 1955 to 2004
Cited by
26 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献