Dengue during pregnancy and live birth outcomes: a cohort of linked data from Brazil

Author:

Paixão Enny SORCID,Campbell Oona M,Teixeira Maria Gloria,Costa Maria CN,Harron KatieORCID,Barreto Mauricio L,Leal Maira B,Almeida Marcia F,Rodrigues Laura C

Abstract

ObjectivesDengue is the most common viral mosquito-borne disease, and women of reproductive age who live in or travel to endemic areas are at risk. Little is known about the effects of dengue during pregnancy on birth outcomes. The objective of this study is to examine the effect of maternal dengue severity on live birth outcomes.Design and settingWe conducted a population-based cohort study using routinely collected Brazilian data from 2006 to 2012.ParticipatingWe linked birth registration records and dengue registration records to identify women with and without dengue during pregnancy. Using multinomial logistic regression and Firth method, we estimated risk and ORs for preterm birth (<37 weeks’ gestation), low birth weight (<2500 g) and small for gestational age (<10thcentile). We also investigated the effect of time between the onset of the disease and each outcome.ResultsWe included 16 738 000 live births. Dengue haemorrhagic fever was associated with preterm birth (OR=2.4; 95% CI 1.3 to 4.4) and low birth weight (OR=2.1; 95% CI 1.1 to 4.0), but there was no evidence of effect for small for gestational age (OR=2.1; 95% CI 0.4 to 12.2). The magnitude of the effects was higher in the acute disease period.ConclusionThis study showed an increased risk of adverse birth outcomes in women with severe dengue during pregnancy. Medical intervention to mitigate maternal risk during severe acute dengue episodes may improve outcomes for infants born to exposed mothers.

Funder

National Council for Scientific and Technological Development

Wellcome Trust

European Union horizon 2020

Publisher

BMJ

Subject

General Medicine

Reference27 articles.

1. World Health Organization. Dengue and severe dengue WHO Fact Sheet No117. 2017 http://www.who.int/mediacentre/factsheets/fs117/en/ (Accessed 4 May 2017).

2. Dengue during pregnancy and adverse fetal outcomes: a systematic review and meta-analysis

3. Symptomatic Dengue Infection during Pregnancy and Infant Outcomes: A Retrospective Cohort Study

4. Dengue Infection in Pregnancy

5. Dengue y embarazoen antioquia, Colombia;Restrepo;Revista Facultad Nacional de Salud Pública,2004

Cited by 22 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3