Study design and rationale for the PAASIM project: a matched cohort study on urban water supply improvements and infant enteric pathogen infection, gut microbiome development and health in Mozambique

Author:

Levy KarenORCID,Garn Joshua V,Cumbe Zaida Adriano,Muneme Bacelar,Fagnant-Sperati Christine SORCID,Hubbard Sydney,Júnior Antonio,Manuel João Luís,Mangamela Magalhães,McGunegill Sandy,Miller-Petrie Molly KORCID,Snyder Jedidiah S,Victor Courtney,Waller Lance AORCID,Konstantinidis Konstantinos T,Clasen Thomas F,Brown JoeORCID,Nalá Rassul,Freeman Matthew CORCID

Abstract

IntroductionDespite clear linkages between provision of clean water and improvements in child health, limited information exists about the health impacts of large water infrastructure improvements in low-income settings. Billions of dollars are spent annually to improve urban water supply, and rigorous evaluation of these improvements, especially targeting informal settlements, is critical to guide policy and investment strategies. Objective measures of infection and exposure to pathogens, and measures of gut function, are needed to understand the effectiveness and impact of water supply improvements.Methods and analysisIn the PAASIM study, we examine the impact of water system improvements on acute and chronic health outcomes in children in a low-income urban area of Beira, Mozambique, comprising 62 sub-neighbourhoods and ~26 300 households. This prospective matched cohort study follows 548 mother–child dyads from late pregnancy through 12 months of age. Primary outcomes include measures of enteric pathogen infections, gut microbiome composition and source drinking water microbiological quality, measured at the child’s 12-month visit. Additional outcomes include diarrhoea prevalence, child growth, previous enteric pathogen exposure, child mortality and various measures of water access and quality. Our analyses will compare (1) subjects living in sub-neighbourhoods with the improved water to those living in sub-neighbourhoods without these improvements; and (2) subjects with household water connections on their premises to those without such a connection. This study will provide critical information to understand how to optimise investments for improving child health, filling the information gap about the impact of piped water provision to low-income urban households, using novel gastrointestinal disease outcomes.Ethics and disseminationThis study was approved by the Emory University Institutional Review Board and the National Bio-Ethics Committee for Health in Mozambique. The pre-analysis plan is published on the Open Science Framework platform (https://osf.io/4rkn6/). Results will be shared with relevant stakeholders locally, and through publications.

Funder

National Institute of Allergy and Infectious Diseases

Autoridade Reguladora de Água, Instituto Público

National Institute of Environmental Health Sciences

Publisher

BMJ

Subject

General Medicine

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