Association between adiponectin and newly diagnosed type 2 diabetes in population with the clustering of obesity, dyslipidaemia and hypertension: a cross-sectional study

Author:

Hong Xiaosi,Zhang Xiaoyun,You LiliORCID,Li Feng,Lian Hong,Wang JiahuanORCID,Mao Na,Ren MengORCID,Li Yan,Wang Chuan,Sun KanORCID

Abstract

ObjectivesAdiponectin is closely related to glucose metabolism and traditional diabetes risk factors (obesity, hypertension and dyslipidaemia). We aimed to explore the association between adiponectin levels and newly diagnosed type 2 diabetes mellitus (T2DM) and pre-diabetes in subgroups classified according to T2DM risk factors.SettingSun Yat-sen Memorial Hospital of Sun Yat-sen University.Participants3680 individuals (1753 men and 1927 women) aged 18–70 years from Guangzhou and Dongguan, China, were enrolled from December 2018 to October 2019.Primary and secondary outcome measuresT2DM was defined as fasting plasma glucose (FPG)≥7.0 mmol/L or HbA1c≥6.5%, and pre-diabetes was defined as 6.1 mmol/L≤FPG<7.0 mmol/L or 5.7≤HbA1c<6.5%.ResultsWith the increasing number of T2DM risk factors, the proportion of the population with high-quartile adiponectin levels gradually decreased (p<0.001). A low level of adiponectin was significantly associated with diabetes and pre-diabetes in a population with ≥1 T2DM risk factor, whereas its association was not consistently significant in the population with all three T2DM risk factors. For instance, participants were more likely to have diabetes or prediabetes with low levels of adiponectin when they had ≥ one T2DM risk factor (quartile 2 vs. 1: OR 0.71 [95%CI: 0.56–0.89]; P=0.003; quartile 3 vs. 1: OR 0.57 [95%CIs: 0.44–0.72]; P<0.001; and quartile 4 vs. 1: OR 0.52 [95%CIs: 0.40–0.67]; P<0.001).ConclusionAdiponectin was negatively associated with diabetes and pre-diabetes in a population with few T2DM risk factors, while their relationship gradually attenuated with the accumulation of T2DM risk factors, especially in a population with coexisting diseases such as obesity, hypertension and dyslipidaemia.

Funder

Guangzhou Basic Research Program [Basic and Applied Basic Research Project]

Natural Science Foundation of Guangdong Province

Sun Yat-sen Clinical Research Cultivating Program

Medical Science and Technology Research Fund Project of Guangdong Province

Natural Science Foundation of China

Science and Technology Planning Project of Guangdong Province, China

National Key Research and Development Project of China

Sun Yat-sen University Clinical Research 5010 Program

Publisher

BMJ

Subject

General Medicine

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3