Acupuncture for emotional disorders in patients with inflammatory bowel disease: a systematic review protocol

Author:

Zhou Yuan-FangORCID,Zhang Gui-LongORCID,Sun NingORCID,Wang Zhong-Quan,Ye Xiang-Yin,Xiong Jian,Deng Xiao-Dong,Lin Xin,Zhang Pei,Zheng Hao,Zhang Yong,Yang Kun,Gao Ze-Da,Sun Rui-RuiORCID,Liang Fan-RongORCID

Abstract

IntroductionEmotional disorders are often observed in inflammatory bowel disease (IBD). IBD with emotional disorders leads to poor quality of life. This systematic review aims to assess the effectiveness of acupuncture in patients with IBD with emotional disorders.Methods and analysisNine electronic databases, including Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE, Allied and Complementary Medicine Database, Cumulative Index to Nursing & Allied Health Literature, China National Knowledge Infrastructure, Chinese Biomedical Literature Database, VIP Database and Wanfang Database, will be searched from inception to October 2021 without language restriction. The grey literature containing conference proceedings, as well as systematic reviews listed in the reference of definite publications, will also be retrieved. Randomised controlled trials either in English or Chinese reporting acupuncture therapy for IBD with emotional disorders will be included. The primary outcome is changes of emotional functioning outcomes. The Colitis Activity Index, Crohn’s Disease Activity Index, C reactive protein and adverse events will be assessed as the secondary outcomes. More than two assessors will conduct the study retrieval and selection, as well as the data extraction and evaluation of the risk of bias. Data synthesis will be performed using a random-effects model based on the results of heterogeneity. Data analysis will be performed using RevMan software (V.5.4). Moreover, the dichotomous data will be presented as risk ratios, and the continuous data will be calculated using weighted mean difference or standard mean difference.Ethics and disseminationThis systematic review contains no individual patient data; thus, ethical approval is not required. Moreover, this review will be disseminated in a peer-reviewed journal or relevant conference.PROSPERO registration numberCRD42020176340.

Funder

China Postdoctoral Science Foundation

Special Project of “Central Government Guides Local Science and Technology Development” in Sichuan Provincial Department of Science and Technology

National Natural Science Foundation of China for the Youth

“Xinglin Scholars” Subject Talent Research Promotion Plan of Chengdu University of Traditional Chinese Medicine

Publisher

BMJ

Subject

General Medicine

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