Author:
Dunne Thomas Frederick,Geberhiwot Tarekegn,Jones Rowena
Abstract
Glycogen storage disease type 1 (GSD-1) is a group of inherited metabolic disorders characterised by the inability to use intracellular glucose stores. It is associated with a high risk of hypoglycaemia, as well as long-term complications including growth retardation, hepatocellular adenomas, renal disease, hypertriglyceridaemia and hyperuricaemia. Treatment involves slow absorption carbohydrates, for example, cornstarch. We present a case of acute psychosis in a patient with GSD-1a. This was initially attributed to his opiate use. Later in his management an MRI scan of his head was performed which revealed regions of brain atrophy following significant hypoglycaemic insult, thus identifying an organic cause of his psychosis. This case presents a rare complication of glycogen storage disease: organic psychosis attributable to cortical atrophy from profound hypoglycaemic insult. It emphasises the importance of investigating organic causes of psychiatric symptoms.
Reference21 articles.
1. Glucose-6-phosphatase deficiency
2. Chen YT . Glycogen storage diseases. In: Scriver CR , Beaudet AL , Sly WS , eds. The Metabolic Bases of Inherited Disease. 8th edn. New-York: McGraw-Hill, 2000:1521–51.
3. Glycogen storage disease type I: diagnosis, management, clinical course and outcome. Results of the European study on glycogen storage disease type I (ESGSD I)
4. Smit GPA , Rake JP , Akman HO , et al . The Glycogen-Storage Diseases and Related Disorders “Liver glycogenoses”. In: Fernandes J , Saudubray JM , van den Berghe G , eds. Inborn Metabolic Diseases. 4th edn. Heidelberg: Springer Medizin Verlag, 2006:p101–12.
5. Kishnani PS , Austin SL , Abdenur JE , et al . Diagnosis and management of glycogen storage disease type I: a practice guideline of the American College of Medical Genetics and Genomics. Genet Med 2014;16:e1.doi:10.1038/gim.2014.128
Cited by
2 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献