Author:
Sfeir Maroun M,Schuetz Audrey,Van Besien Koen,Borczuk Alain C,Soave Rosemary,Jenkins Stephen G,Walsh Thomas J,Small Catherine B
Abstract
IntroductionMycobacterial spindle cell pseudotumour (MSP) is a rare disease characterised by tumour-like local proliferation of spindle-shaped histiocytes containing acid-fast positive mycobacteria. The aim of this literature review is to describe the clinical parameters and treatment outcomes of patients with MSP.MethodsA literature search was conducted using the search terms related to mycobacteria and spindle cell tumours. A previously unreported stem cell transplant recipient from our institution diagnosed with MSP was also included. Demographics, comorbidities, site of infection, treatment and clinical outcomes were analysed.ResultsFifty-one patients were analysed. Twenty-six (51%) had HIV infection.Mycobacterium aviumcomplex was the most frequent organism isolated in 24 (47.1%) followed byMycobacterium tuberculosiscomplex in eight (16%) cases. Lymph nodes were the most common site of infection (45.1%). Twenty (39.2%) patients received antimycobacterial agents, 12 (23.5%) underwent surgical resection and six (11.8%) received antimycobacterial agents plus surgery. Treatment was successful in 24 (47.1%) patients and failed in 15 (29.4%); 13 of these 15 patients died. Antimycobacterial therapy was significantly associated with successful outcome compared with surgical resection or no treatment (P<0.001).ConclusionMSP is a rare condition associated primarily with immunodeficiencies. Antimycobacterial therapy is significantly associated withsuccessfuloutcome.
Subject
General Medicine,Pathology and Forensic Medicine
Cited by
27 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献