Is metformin use associated with a reduced risk of oesophageal cancer? A systematic review and meta-analysis

Author:

Chen Yue,Cheng Xingyu,Sun ChenyuORCID,Kim Na Hyun,Kailas Sujatha,Qureshi Faisal,Karadsheh Zeid,Wu Yile,Hu Lei,Zhou Zhen,Bhan Chandur,Kim Keun Young,Manem Raveena,Cheng Ce,Zhou Qin

Abstract

ObjectivesStudies on the association between metformin use and the risk of oesophageal cancer (OC) have generated controversial findings. This updated meta-analysis was conducted to reassess the effects of metformin on OC.MethodsA comprehensive search strategy was conducted to select relevant studies from origination to February 2021. Heterogeneity was evaluated through the Q test and I2 statistics. HRs and 95% CIs were pooled through either random-effect or fixed-effect models. Meta-regression, subgroup analyses, sensitivity analysis and publication bias diagnosis were also performed.ResultsSeven studies with 5 426 343 subjects were included. Metformin use was associated with reduced risk of OC (HR=0.69, 95% CI 0.54 to 0.87, p<0.001). Sensitivity analysis suggested that the results were relatively stable.ConclusionMetformin is associated with a reduced risk of OC. More well-designed studies are still needed to further elaborate on these associations.PROSPERO registration numberCRD42021237127.

Publisher

BMJ

Subject

General Medicine

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